Adaptation to fluctuations in nutrient availability is a fact of life for single-celled organisms in the ‘wild’. A decade ago our understanding of how bacteria adjust cell cycle parameters to accommodate changes in nutrient availability stemmed almost entirely from elegant physiological studies completed in the 1960s. This article summarizes recent groundbreaking work in this area and discuss potential mechanisms by which nutrient availability and metabolic status are coordinated with cell growth, chromosome replication and cell division.
Metabolism, cell growth and the bacterial cell cycle. Nature Reviews Microbiology 7, 822 (2009)
A day in the life of a cyanobacterium
How smart are bacteria?